Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors

Table 2 Univariate and multivariate analysis of factors affecting prognosis in GISTs

Variable		Univariate analysis				Multivariate analysis
	Yr	P > |z|		95%CI		P > |z|		95%CI
Gender
Male vs Female	10/5	0.448/0.140	0.754/0.547	0.364/0.246	1.563/1.219
Age in yr
≤ 60 vs > 60	10/5	0.964/0.524	0.983/0.767	0.469/0.339	2.060/1.735
Tumor size in cm
< 5 vs 5-10 vs > 10	10/5	0.004/0.019	2.417/2.160	1.336/1.137	4.371/4.102	0.0470	1.876	1.010	3.487
Mitotic index/5 HPFs
0-5 vs 6-10 vs > 10	10/5	< 0.001/< 0.001	2.696/2.727	1.687/1.645	4.310/4.522	0.002/0.001	2.177/2.335	1.345/1.401	3.523/3.889
Gross classification
Single vs Multiple	10/5	0.300/ 0.315	1.569/1.601	0.670/ 0.639	3.677/4.009
Tumor location
Stomach vs Intestine	10/5	0.185/0.281	1.396/1.339	0.853/0.787	2.284/2.279
CCR8 expression
High vs Low	10/5	0.011/0.005	2.738/4.651	1.261/1.593	5.949/13.580	0.037/0.027	2.663/3.432	1.062/1.151	6.677/10.232

P < 0.05. CCR8: A proliferation-inducing ligand; GISTs: Gastrointestinal stromal tumors; HPFs: High-power fields; CI: Confidence interval.