Role of nutritional status and nutritional support in outcome of hepatitis B virus-associated acute-on-chronic liver failure

Table 1 Baseline characteristics of compensated cirrhosis and hepatitis B virus-associated acute-on-chronic liver failure patients enrolled in Study 1, n (%)

Characteristic	HBV-ACLF	Control	P value
n	234	234
Age, yr	46.7 ± 10.8	46.7 ± 10.8	1.000
Male	202 (86.3)	202 (86.3)	1.000
HBeAg positive	98 (41.9)	118 (50.4)	0.064
HBV-DNA (log10 IU/mL)	6.14 (1.85, 8.13)	5.95 (1.74, 7.14)	0.112
PLT (109/L)	120.2 ± 49.1	109.6 ± 43.7	0.014
ALT (IU/L)	680 (421, 1191)	53 (37,114)	< 0.001
AST (IU/L)	592 (313, 980)	41 (23,60)	< 0.001
ALB (g/L)	33.6 ± 4.9	39.9 ± 6.8	< 0.001
TBIL (µmol/L)	274.1 (166.1, 588.7)	17.3 (12.8, 22.5)	< 0.001
PTA (%)	34 (14, 40)	59 (43, 119)	< 0.001
INR	2.46 ± 0.18	1.13 ± 0.09	< 0.001
BUN (mmol/L)	6.1 (3.1, 8.7)	4.8 (3.4, 7.2)	0.001
Cr (μmol/L)	73 (66, 104)	68 (51, 89)	0.012
SBP	124 (53.0)	0	< 0.001
Hepatic encephalopathy	97 (41.5)	0	< 0.001
Hepatorenal syndrome	24 (10.3)	0	< 0.001
MELD score	25.4 ± 4.8	8.2 ± 3.2	< 0.001

Data are presented as the mean ± SD, median (IQR), or n (%). ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; Cr: Creatinine; HBeAg: Hepatitis B e antigen; HBV-ACLF: hepatitis B virus-associated acute-on-chronic liver failure; INR: International normalized ratio; SBP: Spontaneous bacterial peritonitis; MELD: Model for end-stage liver disease; PLT: Platelet; PTA: Prothrombin activity; TBIL: Total bilirubin level.