Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats

Figure 4 Celecoxib attenuates hepatocyte apoptosis by inhibiting the expression of unfolded protein response-related pathway proteins. A: Hepatic activating transcription factor 6 (ATF6), PKR-like endoplasmic reticulum protein kinase, ATF4, X-box binding protein-1, and inositol-requiring enzyme 1 protein expression measured by Western blot. n = 6/group; B: Quantitative Western blot results. ^aP < 0.05 vs TAA + celecoxib group; ^bP < 0.01 vs control group. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; ATF6: Activating transcription factor 6; PERK: PKR-like endoplasmic reticulum protein kinase; XBP1: X-box binding protein-1; IRE1: Inositol-requiring enzyme 1; TAA: Thioacetamide.