Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

doi:10.3748/wjg.v26.i28.4140

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2020; 26(28): 4140-4150
Published online Jul 28, 2020. doi: 10.3748/wjg.v26.i28.4140

Table 4 Analysis of correlations between Bax and Bcl-xL expression in primary colorectal cancer

Groups of patients			Bax–Bcl-xL
Groups of patients		n	P value	r
All		115	< 0.001	0.556^a
Age(yr)	≤ 60	39	< 0.001	0.575^a
Age(yr)	> 60	74	< 0.001	0.530^a
Sex	Male	60	< 0.001	0.453^a
Sex	Female	54	< 0.001	0.643^a
Localization	Rectum	48	< 0.001	0.490^a
Localization	Colon	66	< 0.001	0.594^a
HP–type	A	93	< 0.001	0.546^a
HP–type	MA	22	0.013	0.519^a
G	G2	80	< 0.001	0.523^a
G	G3	34	< 0.001	0.543^a
T	pT1 + pT2	10	0.537	0.222
T	pT3 + pT4	105	< 0.001	0.577^a
N	pN (-)	55	< 0.001	0.509^a
N	pN (+)	60	< 0.001	0.582^a

Associations were analyzed by Spearman's correlation rank test.

^aP < 0.05; n: Number of cases; r: Correlation coefficient; A: Adenocarcinoma; MA: Mucinous adenocarcinoma; G2: Moderately differentiated; G3: Poorly differentiated; N (-): Negative lymph node invasion; N (+): Positive lymph node invasion.

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Citation: Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150
URL: https://www.wjgnet.com/1007-9327/full/v26/i28/4140.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i28.4140

Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150 [PMID: 32821075 DOI: 10.3748/wjg.v26.i28.4140]

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