Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

Table 4 Analysis of correlations between Bax and Bcl-xL expression in primary colorectal cancer

Groups of patients			Bax–Bcl-xL
		n	P value	r
All		115	< 0.001	0.556a
Age(yr)	≤ 60	39	< 0.001	0.575a
	> 60	74	< 0.001	0.530a
Sex	Male	60	< 0.001	0.453a
	Female	54	< 0.001	0.643a
Localization	Rectum	48	< 0.001	0.490a
	Colon	66	< 0.001	0.594a
HP–type	A	93	< 0.001	0.546a
	MA	22	0.013	0.519a
G	G2	80	< 0.001	0.523a
	G3	34	< 0.001	0.543a
T	pT1 + pT2	10	0.537	0.222
	pT3 + pT4	105	< 0.001	0.577a
N	pN (-)	55	< 0.001	0.509a
	pN (+)	60	< 0.001	0.582a

Associations were analyzed by Spearman's correlation rank test.

^aP < 0.05; n: Number of cases; r: Correlation coefficient; A: Adenocarcinoma; MA: Mucinous adenocarcinoma; G2: Moderately differentiated; G3: Poorly differentiated; N (-): Negative lymph node invasion; N (+): Positive lymph node invasion.