Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

Table 3 Analysis of correlations between Insulin receptor substrate 1 and Ki-67 expression in primary colorectal cancer

Groups of patients			IRS-1 – Ki-67
		n	P value	r
All		102	0.589	0.054
Age (yr)	≤ 60	32	0.291	-0.193
	> 60	68	0.147	0.178
Sex	Male	55	0.893	0.018
	Female	46	0.517	0.098
Localization	Rectum	45	0.662	-0.067
	Colon	56	0.285	0.145
HP–type	A	85	0.751	0.035
	MA	17	0.239	-0.302
G	G2	71	0.845	0.024
	G3	30	0.714	0.070
T	pT1 + pT2	8	0.043	0.723a
	pT3 + pT4	94	0.973	-0.004
N	pN (-)	49	0.471	0.105
	pN (+)	53	0.999	0.000

Associations were analyzed by Spearman's correlation rank test.

^aP < 0.05; n: Number of cases; r: Correlation coefficient; A: Adenocarcinoma; MA: Mucinous adenocarcinoma; G2: Moderately differentiated; G3: Poorly differentiated; N (-): Negative lymph node invasion; N (+): Positive lymph node invasion.