Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

Table 1 Analysis of correlation between insulin receptor substrate 1 expression and clinicopathologic features, n (%)

Clinicopathological features		IRS-1 expression		P Fisher exact test
		Weak (0), n = 66	Strong (1+, 2+), n = 61
Age (yr)	≤ 60 (n = 42)	22 (33.8)	20 (33.3)	0.552
	> 60 (n = 83)	43 (66.2)	40 (66.7)
Gender	Male (n = 70)	37 (56.1)	33 (54.1)
	Female (n = 56)	28 (42.4)	28 (45.9)
Tumor Localization	Rectum (n = 57)	33 (50.8)	24 (39.3)	0.134
	Colon (n = 69)	32 (49.2)	37 (60.7)
Histological Typea	A (n = 104)	46 (69.7)	58 (95.1)	< 0.001
	MA (n = 23)	20 (30.3)	3 (4.9)
Histological differentiationa	G2 (n = 87)	35 (53.8)	52 (85.2)	< 0.001
	G3 (n = 39)	30 (46.2)	9 (14.8)
Tumor size	pT1 + pT2 (n = 11)	7 (10.6)	4 (6.6)	0.312
	pT3 + pT4 (n = 116)	59 (89.4)	57 (93.4)
Lymph node Involvement	Negative (n = 60)	29 (43.9)	31 (50.8)	0.438
	Positive (n = 67)	37 (56.1)	30 (49.2)

Correlations were analyzed by Fisher exact test.

^aP < 0.05; n: Number of cases; r: Correlation coefficient; A: Adenocarcinoma; MA: Mucinous adenocarcinoma; G2: Moderately differentiated; G3: Poorly differentiated; N (-): Negative lymph node invasion; N (+): Positive lymph node invasion.