Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation

Table 2 Histopathologic features of Primary sclerosing cholangitis-Ulcerative colitis and Primary sclerosing cholangitis-Crohn disease patients, n (%)

	PSC-UC1	UC1	P value	PSC-CD1	CD1	P value	P value (PSC-UC vs PSC-CD)
Distribution of disease
Right colon only	7 (29)	1 (4)	0.03a	3 (50)	2 (33)	0.6	0.3
Left colon only	1 (4)	7 (26)	0.06	0	0	1	0.9
Left and right colon	16 (67)	17 (63)	0.8	3 (50)	4 (67)	0.6	0.4
Rectum	15 (68)	18 (90)	0.1	1 (20)	5 (83)	0.055	0.07
Ileitis	4 (31)	1 (7)	0.1	5 (100)	4 (67)	0.9	0.9
Severity of disease (active inflammation)
Right colon (average activity score)	1.25	0.96	0.2	1.5	1	0.3	0.5
Left colon (average activity score)	1.2	1.82	0.03a	0.83	0.86	0.9	0.4
Rectum (average activity score)	0.96	2.05	0.0006a	0.2	1.17	0.1	0.1
Ileum (average activity score)	0.31	0.07	0.2	1	1	1	0.01a
Max average activity score at any site	1.46	2.29	0.0005a	1.83	1.67	0.7	0.3
Architectural distortion
Right colon	24 (100)	21 (78)	0.9	6 (100)	6 (100)	1	1
Left colon	24 (96)	26 (93)	0.6	6 (100)	7 (100)	1	0.9
Rectum	18 (78)	19 (95)	0.1	5 (100)	5 (83)	0.9	0.9
Any site	26 (100)	28(100)	1	6 (100)	9 (100)	1	1
Paneth cell metaplasia
Left colon	11 (44)	14 (50)	0.7	1 (17)	4 (57)	0.1	0.2
Rectum	5 (22)	6 (30)	0.5	1 (20)	0	0.9	0.9
Basal plasmacytosis
Right colon	14 (58)	13 (48)	0.5	2 (33)	3 (50)	0.5	0.3
Left colon	11 (44)	22 (79)	0.01a	0	4 (57)	0.9	0.9
Rectum	6 (26)	19 (95)	0.0004a	1 (20)	3 (50)	0.3	0.7
Any site	16 (62)	27 (96)	0.01a	3 (50)	7 (78)	0.2	0.6
Pyloric gland metaplasia
Right colon	2 (8)	1 (4)	0.7	1 (17)	1 (17)	1	0.6
Left colon	0	0	1	0	0	1	1
Any site	2 (8)	1 (4)	0.5	1 (17)	1 (11)	0.7	0.5
Granulomas
Any site	1 (4)	0	0.9	1 (17)	6 (67)	0.08	0.3

^aP < 0.05.

¹In all biopsied sites. PSC: Primary sclerosing cholangitis; UC: Ulcerative colitis; CD: Crohn diseas; NA: Not available.