Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients

Table 4 Diagnostic value of ceruloplasmin hepatitis B virus in the training and validation groups

Variable	Training group (n = 138)			Validation group (n = 137)
	F ≥ 2	F ≥ 3	F = 4	F ≥ 2	F ≥ 3	F = 4
AUC	0.842	0.920	0.904	0.805	0.886	0.863
95%CI	0.777-0.907	0.872-0.967	0.842-0.955	0.733-0.877	0.827-0.946	0.784-0.943
Cut-off	0.0304	0.496	0.553	0.174	0.176	0.206
Sensitivity, %	81.1	90.9	96.2	72.4	89.1	97.1
Specificity	71.9	78.7	71.4	80.3	72.5	70.6
Youden’s index	0.530	0.696	0.676	0.527	0.616	0.677
PPV	76.9	66.7	43.9	82.1	62.1	53.1
NPV	76.7	94.9	98.8	70.0	93.0	98.6

AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.