TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma

Table 3 Multivariate analysis of overall survival

Parameter	Category	Hazard ratio	95%CI	P value
Age (yrs)	< 60	0.139	0.907 (0.544–1.514)	0.709
	≥ 60
Sex	Male	0.013	1.031 (0.613–1.734)	0.908
	Female
Histopathological subtypes	High	0.536	1.184 (0.754–1.859)	0.464
	Middle
	Low
TNM stage	1-II	5.692	3.046 (1.220–7.604)	0.017a
	III-IV
Tumor size	< 3 cm	1.297	1.378 (0.794–2.394)	0.255
	≥ 3 cm
Tumor location	Head	3.450	1.487 (0.978–2.261)	0.063
	Body/tail
Lymph node metastasis	Negative	7.855	2.231 (1.273–3.909)	0.005b
	Positive
TBL1XR1 expression	Low	13.951	3.507 (1.815–6.774)	< 0.001c
	High

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.TBL1XR1: Transducin (β)-like 1 X-linked receptor 1; CI: Confidence interval; TNM: Tumor-node-metastasis.