Clinical efficacy of the over-the-scope clip device: A systematic review

Table 5 Summary of prospective studies (overall clinical success rate, per-indication clinical success rate and adverse event rate)

Ref.	Year	Type of study	Country	Patients (n)	Overall clinical success rate (%)							Follow-up (wk)	Adverse events, n (%)
					Indications						Total
					Fistula	Bleeding	Perforation	Leak	ER3	Stent fixation
Maekawa et al[21]	2015	Prospective	Japan	12	-	-	-	-	11/12	-	11/12	NR	0.0
Voermans et al[24]	2012	Prospective Multi-center	Netherlands	36	-	-	32/36	-	-	-	32/26	1-26	0.0
Lee et al[26]	2017	Prospective Multi-center	Korea	19	1/4	-	1/1	10/12	1/2	-	13/19	72	0.0
Arezzo et al[28]	2012	Case series Prospective	Italy	14	-	-	-	12/14	-	-	12/14	16	0.0
Schlag et al[29]	2013	Prospective	Germany	6	-	-	6/6	-	-	-	6/6	4-12	0.0
Gubler et al [31]	2012	Case series Prospective	Switzerland	14	-	-	12/14	-	-	-	12/14	4-48	NR
Singhal et al[32]	2014	Case series Prospective	United States	10	9/10	-	-	-	-	-	9/10	7	0.0
Schmidt et al[4]	2015	Prospective Multi-center RCT	International1	24	-	-	-	-	18/24	-	18/24	4	2 (8.3)
Correia et al[36]	2014	Case series Prospective	Portugal	6	4/5	-	1/1	-	-	-	5/6	NR	0.0
Goenka et al[37]	2017	Prospective	India	12	2/3	6/6	3/3	-	-	-	11/12	4-8	0.0
Surace et al[38]	2011	Prospective	Italy	19	14/19	-	-	-	-	-	14/19	32	1 (5.3)
Kochhar et al[39]	2017	Case series Prospective	United States	12	-	-	-	8/12	-	-	8/12	60	1 (8.3)
Manta et al[40]	2017	Prospective	Italy	76	-	-	-	61/76	-	-	61/76	NR	0.0
Parodi et al[41]	2010	Prospective	Italy	10	4/5	-	3/3	1/2	-	-	8/10	NR	0.0
Sulz et al[52]	2014	Case series Prospective	Switzerland	19	6/11	1/1	-	4/6	-	1/1	12/19	NR	0.0
Magdeburg et al[53]	2015	Prospective	Germany	43	-	-	42/43	-	-	-	42/43	NR	3 (7.0)
Keren et al[55]	2014	Case series Prospective	Israel	26	-	-	-	21/26	-	-	21/26	NR	0.0
Hagel et al[57]	2012	Case series Prospective	Germany	17	-	-	11/17	-	-	-	11/17	4	NR
Mangiafico et al[63]	2017	Case series Prospective	International2	7	7/7	-	-	-	-	-	7/7	2-8	0.0
Schmdtt et al[4]	2018	Prospective RCT	International3	33	-	28/33	-	-	-	-	28/33	4	0.0
Prosst et al[66]	2015	Prospective	Germany	20	18/20	-	-	-	-	-	18/20	24	0.0
Mizrahi et al[67]	2016	Prospective	United States	51	6/17	3/4	3/4	12/24	-	1/2	25/51	48	NR
Chan et al [75]	2014	Case series Prospective	China	9	-	7/9	-	-	-	-	7/9	8	NR
Keen et al[76]	2019	Prospective	United Kingdom	59	-	55/59	-	-	-	-	55/59	4	NR
Tashima et al[85]	2017	Prospective	Japan	50	-	-	-	-	47/50	-	47/50	2	4 (8)
Kappelle et al[89]	2018	Prospective	Netherlands	13	-	-	-	-	11/13	-	11/13	24	5 (38.4)
Total				617	70.3%	89.3%	89.1%	75.0%	87.1%	66.7%	81.7%	-	3.4%
					71/101	100/112	114/128	129/172	88/101	2/3	504/617	-	16/4674

¹Switzerland, Germany.

²Italy, United Kingdom.

³Germany, China, Switzerland.

⁴Over the scope clip-related adverse events were only reported for 467 of 617 patients (n = 21 studies). NR: Not reported; ER: Endoscopic resection; RCT: Randomized control trial.