Non-invasive tests for the prediction of primary hepatocellular carcinoma

Table 3 Studies reporting the role of transient elastography in predicting hepatocellular carcinoma

Ref.	Etiology	Patients (n)	Follow-up (mo)	Region	HCC (n)	AUROC	Cut-off (kPa)
Masuzaki et al[110], 2008	HCV	265	-	Asia	85	0.805	25
Nahon et al[116], 2009	HCV	265	-	Europe	66	-	-
Masuzaki et al[115], 2009	HCV	866	36.0	Asia	77	-	25
Kuo et al[117], 2010	HBV, HCV, non-B/non-C	435	-	Asia	106	0.736	24
Akima et al[118], 2011	Mixed (HCV: 85%)	157	40.7	Asia	41	0.787	12.5
Jung et al[90], 2011	HBV	1130	30.7	Asia	57	-	8
Fung et al[91], 2011	HBV	528	35.0	Asia	7	-	10
Robic et al[94], 2011	Mixed	100	24.0	Europe	4	0.837	21.1
Klibansky et al[95], 2012	Mixed	667	28.7	USA	16	0.870	10.5
Chon et al[49], 2012	HBV	1126	30.7	Asia	63	0.789	-
Kim et al[92], 2012	HBV	128	27.8	Asia	13	0.722	19
Calvaruso et al[97], 2012	HCV/HIV	275	32	Europe	-	-	14-40
Salmon et al[98], 2012	HCV/HIV	244	30	Europe	21	-	12.5
Perez-Latorre et al[99], 2013	HCV	60	42	Europe	7	0.77	25-40
Feier et al[89], 2013	HCV	144	-	Europe	72	0.680	38.5
Wang et al[119], 2013	HCV	198	47.8	Asia	10	-	12
Narita et al[120], 2013	HCV	151	24.1	Asia	9	-	14
Kim et al[93], 2013	HBV	162	24.0	Asia	12	0.736	12
Poynard et al[96], 2014	HCV	3927	144	Europe	84	0.860	50
Wong et al[100], 2014	HBV	1555	69	Asia	55	0.83	11
Kim et al[102], 2015	HBV	2876	48.9	Asia	52	0.532	13
Wang et al[103], 2016	HCV	278	91.2	Asia	18	0.781	12
Adler et al[105], 2016	Mixed	432	31.3	Europe	41	-	20
Bihari et al[106], 2016	HBV	964	-	Asia	14	0.767
Seo et al[107], 2016	HBV	381	48.1	Asia	34	0.745	-
Jeon et al[104], 2017	HBV	540	54.1	Asia	81	0.598	13
Li et al[101], 2017	HBV	1200	48	Asia	156	-	-
D’Ambrosio et al[108], 2018	HCV	404	36	Europe	24	-	-
Wang et al[109], 2019	HBV	371	67.2	Asia	27	0.636	21.5
Degasperi et al[60], 2019	HCV SVR	546	25	Europe	28	-	30
Rinaldi et al[111], 2019	HCV SVR	258	24	Europe	35	0.691	27.8
Izumi et al[112], 2019	HCV	419	30	Asia	32	0.806	8
Izumi et al[112], 2019	HBV	377	27	Asia	23	0.795	6.2
Izumi et al[112], 2019	NAFLD	258	30	Asia	33	0.698	5.4
Pons et al[113], 2019	HCV SVR	572	33	Europe	25	-	-
Nakagomi et al[114], 2019	HCV	1146	78	Asia	190	-	-

AUROC: Area under receiving operating characteristics curve; kPa: Kilopascal; HCV: Hepatitis virus C; HBV: Hepatitis virus B; HIV: Human immunodeficiency virus; SVR: Sustained virologic response; NAFLD: Non-alcoholic fatty liver disease.