Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis

Table 4 Summary diagnostic performance and subgroup analysis

Characteristics	No.	Sensitivity	Specificity	Positive LR	Negative LR	DOR	AUC
LF ≥ F1	5	0.78 (0.73-0.82)	0.81 (0.74-0.86)	3.93 (2.12-7.27)	0.30 (0.19-0.46)	15.37 (5.74-41.16)	0.862 (0.811-0.914)
LF ≥ F2	9	0.82 (0.79-0.86)	0.80 (0.75-0.84)	3.69 (2.53-5.37)	0.24 (0.16-0.37)	19.35 (9.51-39.34)	0.883 (0.856-0.909)
LF ≥ F3	4	0.85 (0.79-0.90)	0.83 (0.77-0.87)	4.70 (3.51-6.28)	0.21 (0.10-0.44)	22.61 (8.24-62.05)	0.886 (0.865-0.907)
LF = F4	6	0.90 (0.84-0.94)	0.75 (0.70-0.79)	3.36 (2.57-4.38)	0.16 (0.08-0.31)	26.99 (12.88-56.58)	0.899 (0.866-0.932)
Subgroup analysis in LF ≥ F2
Study design
Retrospective	6	0.86 (0.82-0.90)	0.78 (0.71-0.83)	3.73 (2.19-6.34)	0.17 (0.10-0.29)	29.82 (11.65-76.32)	0.921 (0.891-0.952)
Prospective	3	0.71 (0.62-0.79)	0.84 (0.74-0.90)	3.97 (2.42-6.52)	0.42 (0.25-0.69)	10.20 (4.30-24.16)	0.905 (0.862-0.948)
Double blindness
Yes	3	0.80 (0.74-0.85)	0.75 (0.66-0.83)	3.75 (1.69-8.32)	0.25 (0.19-0.33)	15.46 (8.20-29.14)	0.874 (0.848-0.901)
Unclear	6	0.85 (0.80-0.89)	0.82 (0.76-0.87)	3.80 (2.47-5.84)	0.22 (0.10-0.49)	22.39 (6.91-72.51)	0.892 (0.855-0.930)
Field strength
1.5 T	3	0.76 (0.68-0.83)	0.81 (0.68-0.90)	3.16 (1.67-5.99)	0.34 (0.18-0.64)	10.40 (3.51-30.87)	0.839 (0.758-0.919)
3.0 T	6	0.85 (0.81-0.89)	0.79 (0.74-0.84)	3.92 (2.42-6.37)	0.19 (0.10-0.36)	26.17 (10.81-63.36)	0.904 (0.872-0.935)
Low b-values (0-50 s/mm2)
< 2	5	0.81 (0.75-0.86)	0.81 (0.73-0.87)	3.40 (2.17-5.35)	0.26 (0.14-0.47)	17.12 (6.11-47.98)	0.877 (0.834-0.921)
≥ 2	4	0.83 (0.78-0.88)	0.79 (0.72-0.85)	4.11 (2.07-8.17)	0.22 (0.10-0.47)	21.73 (7.22-65.42)	0.890 (0.855-0.935)
Trigger method
RT	5	0.82 (0.77-0.86)	0.79 (0.73-0.84)	3.66 (2.24-5.97)	0.27 (0.14-0.54)	15.05 (5.78-39.22)	0.867 (0.828-0.905)
Non-RT	4	0.83 (0.77-0.88)	0.81 (0.70-0.89)	4.02 (1.85-8.76)	0.21 (0.13-0.34)	29.43 (9.89-87.59)	0.919 (0.883-0.956)

No.: Number of studies; LR: Likelihood ratio; DOR: Diagnostic odds ratio; AUC: Area under summary receiver operating characteristic curves; RT: Respiratory triggered.