Copyright
©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 3098-3109
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3098
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3098
Table 1 Clinical characteristics of the study population
| IL10RA | CD | HC | P value1 | |
| Number of samples | 17 | 17 | 26 | |
| Demographics | ||||
| Age (mean ± SD, yr) | 1.00 ± 0.68 | 8.92 ± 4.80 | 1.61 ± 1.71 | < 0.001 |
| Sex (M/F) | 10/7 | 11/6 | 17/9 | 0.724 |
| Weight and BMI | ||||
| Weight (mean ± SD, kg) | 7.31 ± 2.58 | 27.18 ± 13.04 | NA | < 0.001 |
| BMI (mean ± SD) | 14.53 ± 2.20 | 15.25 ± 2.44 | NA | 0.6175 |
| Disease activity | ||||
| CRP (mean ± SD, mg/L) | 40.65 ± 28.13 | 34.06 ± 31.92 | NA | 0.4486 |
| wPCDAI (mean ± SD) | 52.21 ± 17.65 | 40.88 ± 20.02 | NA | 0.1253 |
| SES-CD (mean ± SD) | 20.56 ± 7.56 | 12.94 ± 8.60 | NA | 0.0158 |
| MINI index (mean ± SD) | 19.88 ± 4.96 | 16.47 ± 2.92 | NA | 0.0027 |
| Disease duration and anemia | ||||
| Disease duration (mean ± SD, mo) | 9.93 ± 7.75 | 7.10 ± 9.30 | NA | 0.0706 |
| Disease location | ||||
| Ileum only (%) | 0 (0) | 3 (18) | NA | < 0.001 |
| Colon only (%) | 17 (100) | 3 (18) | NA | |
| Both (%) | 0 (0) | 11 (64) | NA | |
| Disease behaviour | ||||
| Montreal classification B1 (%) | 11 (65) | 15 (88) | NA | 0.106 |
| Montreal classification B2 (%) | 5 (29) | 2 (12) | NA | 0.203 |
| Montreal classification B3 (%) | 4 (24) | 0 (0) | NA | 0.033 |
| Montreal classification P (%) | 16 (94) | 4 (24) | NA | < 0.001 |
| Serology | ||||
| IL6 (mean ± SD, pg/mL) | 122.47 ± 152.22 | 37.50 ± 25.08 | NA | 0.0211 |
| Birth and breast feeding | ||||
| Cesarian section (%) | 11 (65) | 8 (47) | NA | 0.300 |
| Breast feeding (%) | 14 (82) | 13 (76) | NA | 0.671 |
| IBD medication | ||||
| Mesalazine (%) | 11 (65) | 11 (65) | NA | 1.000 |
| Steroids (%) | 1 (6) | 2 (12) | NA | 0.542 |
| Thalidomide (%) | 4 (24) | 0 (0) | NA | 0.014 |
| Other medication | ||||
| Antibiotics (%) | 13 (76) | 13 (76) | NA | 1.000 |
| Proton pump inhibitors (%) | 1 (6) | 9 (53) | NA | 0.001 |
| Marzulene-S (%) | 1 (6) | 1 (6) | NA | 1.000 |
| Self-reported diets | ||||
| Amino acid formula (%) | 2 (12) | 0 (0) | NA | 0.089 |
| Extensive hydrolyzed formula (%) | 3 (18) | 1 (6) | NA | 0.277 |
| Other diet (%) | 12 (71) | 10 (59) | NA | 0.473 |
- Citation: Xue AJ, Miao SJ, Sun H, Qiu XX, Wang SN, Wang L, Ye ZQ, Zheng CF, Huang ZH, Wang YH, Huang Y. Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations. World J Gastroenterol 2020; 26(22): 3098-3109
- URL: https://www.wjgnet.com/1007-9327/full/v26/i22/3098.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i22.3098