Diagnostic challenges in non-cirrhotic portal hypertension - porto sinusoidal vascular disease

Table 1 Histological differences between porto-sinusoidal vascular disease, extrahepatic portal vein obstruction and cirrhosis

	PSVD	EHPVO	Cirrhosis
Portal and periportal zone
Small portal vein obliteration (“hepato-portal sclerosis", phlebosclerosis)	++	+/-	-
Periportal shunt vessel	++	+	-
Fibrous septa	+/-; without bridging1	-	++; with bridging delimitating nodules
Inflammation	-	-	++
Portal biliopathy	-	+/-	-
Liver lobule (parenchyma)
Perisinusoidal fibrosis	+	-	+/-
Sinusoidal dilatation	++	++	-
Nodular regenerative hyperplasia	+	+	-
Hepatocyte atrophy	+	+	-
Centrilobular zone
Central vein dilatation	++	+		-
Perivenular fibrosis	++	+		-

¹Incomplete septal fibrosis. ++: Almost always present; +: Usually present; +/–: Occasionally present; –: Usually absent; PSVD: Porto-sinusoidal vascular disease; EHPVO: Extrahepatic portal vein obstruction.