Conservation and variability of hepatitis B core at different chronic hepatitis stages

Figure 5 Information content analysis at amino acid level by clinical group. A: Sliding window analysis of the Hepatitis B core protein by haplotype between the different clinical groups (HCC in blue, CHB in red, and LC in green). The green horizontal line corresponds to the region where LC group is less conserved compared to the CHB and HCC groups (P < 0.05). B: Representation of CHB- and LC-specific conserved amino acid regions as sequence logos. Positions are reported at the top of each logo. CHB: Chronic hepatitis B infection without liver damage; HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; aa: Amino acid; P: P value.