Systematic Review
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jan 14, 2020; 26(2): 219-245
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.219
Table 1 Participants, interventions, comparisons, outcomes and study design criteria used to define the research question for this systematic review
VariableDescription
PopulationHumans diagnosed with liver failure (ALF/ACLF)
InterventionPlasma exchange with or without other alternative liver support systems; no restrictions on dose, duration and type of plasma exchange
ComparatorRandomized controlled trials/Cohort studies: Standard medical treatment
Case series/case reports: Nil
OutcomeAll-cause mortality, changes in liver biochemistry, and survival in non-transplanted patients
Study designRandomized Controlled Trials, Cohort studies, Case series, Case reports
Research questionDoes plasmapheresis have an effect on all-cause mortality, changes in liver biochemistry, and survival in non-transplanted patients with ALF/ACLF, compared to standard medical treatment?