Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative

Table 2 Univariate and multivariate analyses of high-cardiovascular disease-risk predictors

Parameters	Univariate analysis				Multivariate analysis
	Exp (B)	95%CI		P value	Exp (B)	95%CI		P value
		Lower	Upper			Lower	Upper
Age (yr)	1.39	1.33	1.45	< 0.01	1.80	1.57	2.05	0.00
BMI (kg/m2)	1.00	0.98	1.02	0.97	0.97	0.84	1.11	0.63
Waist circumference (cm)	1.01	1.00	1.03	0.02	1.03	0.97	1.10	0.37
Ethnic origin: Chinese	0.36	0.27	0.48	< 0.01	0.05	0.01	0.15	0.00
Diabetes	7.34	5.20	10.35	< 0.01	319.11	60.63	1679.65	0.00
Hypertension	2.91	2.18	3.87	< 0.01	1.43	0.56	3.66	0.45
Dyslipidemia	1.55	1.13	2.12	0.01	1.18	0.43	3.25	0.75
Albumin (g/L)	0.87	0.84	0.90	< 0.01	0.96	0.85	1.09	0.56
ALT (U/L)	0.99	0.99	0.99	< 0.01	1.00	0.99	1.01	0.80
GGT (U/L)	1.00	1.00	1.00	0.27
HbA1c (%)	1.36	1.23	1.51	< 0.01	0.97	0.75	1.26	0.80
Total cholesterol (mmol/L)	0.68	0.59	0.78	< 0.01	1.82	0.69	4.80	0.23
LDL cholesterol (mmol/L)	0.58	0.49	0.68	< 0.01	1.05	0.35	3.13	0.93
HDL cholesterol (mmol/L)	0.52	0.35	0.76	< 0.01	0.05	0.01	0.21	0.00
Platelet (109/L)	1.00	0.99	1.00	< 0.01	1.00	0.99	1.01	0.59
Fibrosis stage by liver biopsy	1.53	1.38	1.69	< 0.01	1.12	0.74	1.68	0.60
TE (kPa)	1.06	1.04	1.08	< 0.01	1.00	0.93	1.06	0.91

CI: Confidence interval; BMI: Body mass index; ALT: Alanine transaminase; GGT: Gamma-glutamyl transferase; TE: Transient elastography; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.