Predicting dyslipidemia after liver transplantation: A significant role of recipient metabolic inflammation profile

Table 1 Comparison of perioperative findings between post-transplant dyslipidemia and non-post-transplant dyslipidemia groups

	PTDL (n = 278)	Non-PTDL (n = 118)	P value
Recipient factors
Age (yr)	48.2 ± 9.6	49.1 ± 9.1	0.411
Male, n (%)	237 (85.3)	102 (86.4)	0.758
BMI (kg/m2)	23.2 ± 3.2	22.3 ± 2.9	0.012
MELD score	20.9 ± 10.9	20.6 ± 11.7	0.777
Laboratory value
Creatinine (μmol/L)	65.0 (53.0-83.8)	66.0 (55.0-78.0)	0.925
Albumin (g/L)	34.7 (31.0-38.2)	35.5 (32.2-39.6)	0.218
TB (μmol/L)	63.5 (28.0-335.5)	58.5 (22.3-205.8)	0.066
INR	1.5 (1.3-1.9)	1.4 (1.2-1.7)	0.087
AST (U/L)	66.0 (37.0-128.8)	71.5 (38.3-125.5)	0.694
ALT (U/L)	43 (24.0-93.3)	40.5 (26.0-125.0)	0.621
TC (mg/dL)	100.5 (65.7-139.2)	104.4 (73.5-135.3)	0.947
TG (mg/dL)	88.6 (62.0-115.1)	70.9 (53.1-97.4)	0.017
HDLC (mg/dL)	23.2 (11.6-34.8)	27.1 (15.5-42.5)	0.024
LDLC (mg/dL)	47.6 (27.1-73.5)	46.4 (30.9-69.6)	0.676
VLDLC (mg/dL)	23.2 (15.5-38.7)	19.3 (11.6-30.9)	0.052
FBG (mmol/L)	6.3 (5.3-8.0)	6.0 (5.3-7.4)	0.328
Cirrhosis, n (%)	206 (74.1)	94 (79.7)	0.238
HCC, n (%)	108 (38.8)	61 (51.7)	0.018
HBV status, n (%)
HBsAg positive	215 (77.3)	102 (86.4)	0.038
HBeAg positive	81 (29.1)	27 (22.9)	0.201
HBV DNA > 1000 copies/mL	39 (14.0)	18 (15.3)	0.751
Pre-LT AVT	108 (38.8)	52 (44.1)	0.333
Comorbidities, n (%)
Hepatic encephalopathy	50 (18.0)	25 (21.2)	0.457
Hepatorenal syndrome	22 (7.9)	10 (8.5)	0.851
Gastrointestinal bleeding	57 (20.5)	14 (11.9)	0.040
Ascites	104 (37.4)	31 (26.3)	0.032
Donor factors
Age (yr)	38.8 ± 12.3	41.3 ± 12.8	0.071
Male, n (%)	235 (84.5)	99 (83.9)	0.874
Cause of death, n (%)
Trauma	171 (61.5)	71 (60.2)	0.802
CVA	87 (31.3)	37 (31.4)	0.934
Other	21 (7.6)	10 (8.5)	0.755
DBD (vs DCD)	49 (17.6)	17 (14.4)	0.432
BMI (kg/m2)	22.6 ± 2.6	23.0 ± 2.7	0.169
Graft weight (kg)	1.4 ± 0.3	1.4 ± 0.3	0.228
Macrovesicular steatosis, n (%)	50 (18.0)	22 (18.6)	0.877
Creatinine (μmol/L)	77.0 (56.5-118.5)	82.2 (56.1-121.3)	0.685
Albumin (g/L)	31.0 (28.0-36.5)	30.9 (26.7-36.7)	0.474
TB (μmol/L)	14.1 (9.1-23.4)	16.5 (11.1-26.5)	0.078
AST (U/L)	52.0 (33.0-87.2)	51.5 (31.3-94.5)	0.694
ALT (U/L)	34.0 (22.0-69.0)	39.0 (22.5-76.3)	0.345
Operative factors
WIT (min)	50.7 ± 14.3	47.0 ± 10.8	0.006
CIT (h)	8.4 ± 3.1	8.7 ± 3.4	0.359
Blood loss (L)	1.0 (0.8-2.0)	1.0 (0.8-1.5)	0.117
Immunosuppressant, n (%)
IL2R antibody	204 (73.4)	93 (78.8)	0.254
Corticosteroid	156 (56.1)	58 (49.2)	0.204
Tacrolimus	245 (88.1)	103 (87.3)	0.814

PTDL: Post-transplant dyslipidemia; BMI: Body mass index; MELD: Model for end-stage liver disease; TB: Total bilirubin; INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TC: Total cholesterol; TG: Triglyceride; HDLC: High-density lipoprotein cholesterol; LDLC: Low density lipoprotein cholesterol; VLDLC: Very low-density lipoprotein cholesterol; FBG: Fasting blood glucose; HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus; LT: Liver transplantation; AVT: Antiviral treatment; CVA: Cerebral vascular accident; DBD: Donation after brain death; DCD: Donor after circulatory death; WIT: Warm ischemia time; CIT: Cold ischemia time.