Optimal proximal resection margin distance for gastrectomy in advanced gastric cancer

Table 6 Analysis of the risk factors associated with recurrence-free survival in patients who underwent distal gastrectomy using the Cox proportional hazard model

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.02 (1.00-1.03)	0.011	1.02 (1.00-1.03)	0.012
Female sex	0.93 (0.69-1.25)	0.636
BMI	0.96 (0.92-1.00)	0.068
Tumor location
Upper 1/3	Ref.
Mid 1/3	2.32 (0.32-16.77)	0.403
Lower 1/3	2.35 (0.33-16.76)	0.395
Reconstruction
Billroth I	Ref.		Ref.
Billroth II	1.90 (1.37-2.64)	< 0.001	1.50 (1.08-2.10)	0.016
RYGJ	1.87 (1.31-2.67)	0.001	1.72 (1.20-2.47)	0.003
Tumor size	1.16 (1.10-1.21)	< 0.001
Borrmann type IV	1.04 (0.46-2.33)	0.931
CLN	1.00 (0.99-1.01)	0.91
T stage
T2	Ref.		Ref.
T3	2.61 (1.72-3.96)	< 0.001	1.92 (1.25-2.95)	0.003
T4	6.17 (4.08-9.34)	< 0.001	3.42 (2.21-5.31)	< 0.001
N stage
N0	Ref.		Ref.
N1	1.23 (0.75-2.03)	0.415	1.03 (0.62-1.70)	0.92
N2	3.42 (2.26-5.19)	< 0.001	2.55 (1.67-3.89)	< 0.001
N3	5.75 (3.92-8.42)	< 0.001	3.88 (2.59-5.80)	< 0.001
Diffuse type histology	1.19 (0.91-1.57)	0.206	1.05 (0.79-1.39)	0.758
LVi	2.29 (1.73-3.02)	< 0.001
PNi	1.63 (1.25-2.12)	< 0.001
PRM (cm)
0-1.0	Ref.
1.1-3.0	1.03 (0.37-2.86)	0.949
3.1-5.0	0.78 (0.29-2.15)	0.633
> 5.0	0.84 (0.31-2.29)	0.734

PRM: Proximal resection margin; RYGJ: Roux-en-Y gastrojejunostomy; CLN: Total number of collected lymph nodes; LVi: Lymphovascular invasion; PNi: Perineural invasion.