Optimal proximal resection margin distance for gastrectomy in advanced gastric cancer

Table 5 Analysis of the risk factors associated with overall survival in patients who underwent total gastrectomy using the Cox proportional hazard model

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.02 (1.01-1.03)	< 0.001	1.03 (1.02-1.04)	< 0.001
Female sex	1.03 (0.81-1.30)	0.834
BMI	0.95 (0.92-0.99)	0.009
Tumor location
Upper 1/3	Ref.
Mid 1/3	0.76 (0.60-0.95)	0.018
Lower 1/3	0.94 (0.65-1.35)	0.723
Tumor size	1.09 (1.07-1.12)	< 0.001
Borrmann type IV	2.21 (1.66-2.94)	< 0.001	1.93 (1.43-2.60)	< 0.001
CLN	1.00 (0.99-1.01)	0.548	0.99 (0.98-1.00)	0.035
T stage
T2	Ref.		Ref.
T3	1.67 (1.14-2.45)	0.008	1.21 (0.81-1.81)	0.352
T4	3.24 (2.22-4.72)	< 0.001	1.85 (1.22-2.79)	0.004
N stage
N0	Ref.		Ref.
N1	1.11 (0.74-1.68)	0.617	1.03 (0.67-1.57)	0.900
N2	1.73 (1.21-2.46)	0.003	1.48 (1.01-2.18)	0.045
N3	3.87 (2.88-5.19)	< 0.001	2.81 (1.98-3.98)	< 0.001
Diffuse type histology	1.23 (0.96-1.58)	0.103
LVi	2.09 (1.65-2.64)	< 0.001	1.43 (1.10-1.86)	0.008
PNi	1.60 (1.27-2.00)	< 0.001
PRM (cm)
0-1.0	Ref.
1.1-3.0	0.80 (0.57-1.10)	0.164
3.1-5.0	0.65 (0.45-0.93)	0.019
> 5.0	0.81 (0.58-1.12)	0.202

PRM: Proximal resection margin; RYGJ: Roux-en-Y gastrojejunostomy; CLN: Total number of collected lymph nodes; LVi: Lymphovascular invasion; PNi: Perineural invasion.