Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease

doi:10.3748/wjg.v26.i18.2194

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2020; 26(18): 2194-2202
Published online May 14, 2020. doi: 10.3748/wjg.v26.i18.2194

Table 3 Pairwise statistical interaction between single nucleotide polymorphisms in a linear model¹

SNP	*CLEC5A*	*CLEC7A*		*NOD2*
SNP	rs1285933	rs2078178	rs16910631	rs2066844	rs2066845	rs2066847
rs1285933	NA	0.6490	0. 7409	0.5266	0.6875	0.2813
rs2078178	0.6490	NA	0.1036	0.8573	0.4040	0.3718
rs16910631	0.7409	0.1036	NA	0.8980	0.6698	0.9270
rs2066844	0.5266	0.8573	0.8980	NA	2.8248e-07	0.9664
rs2066845	0.6875	0.4040	0.6698	2.8248e-07	NA	0.7399
rs2066847	0.2813	0.3718	0.9270	0.9664	0.7399	NA

¹Disease—single nucleotide polymorphism (SNP) A + SNP B + SNP A: SNP B. The uncorrected P values for the last term of an ANOVA are presented in the table for all 30 interactions. The only significance was for two chromosomally neighboring SNPs within NOD2. SNP: Single nucleotide polymorphism; NA: Not applicable.

Citation: Elleisy N, Rohde S, Huth A, Gittel N, Glass Ä, Möller S, Lamprecht G, Schäffler H, Jaster R. Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease. World J Gastroenterol 2020; 26(18): 2194-2202
URL: https://www.wjgnet.com/1007-9327/full/v26/i18/2194.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i18.2194