Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease

Table 1 Genotype and allele frequencies of single nucleotide polymorphisms in the genes CLEC5A, CLEC7A and NOD2 in Crohn’s disease patients and controls

Gene	SNP	Genotype	Cases (n = 175)	Controls (n = 157)	Allele1	Cases (alleles)	Controls (alleles)	Genotype P value2	Dominant P value2,3	Recessive P value2,3	Allelic P value2
CLEC5A	rs1285933	GG	35	36	G, A	144, 206	155, 159	0.1093 (0.0285)	0.9727 (0.5921)	0.0523 (0.0091)	0.0900 (0.0352)
		GA	74	83
		AA	66	38
CLEC7A	rs2078178	GG	104	100	G, A	274, 76	251, 63	1.0000 (0.5713)	0.9033 (0.4320)	0.8344 (0.7618)	0.9107 (0.6335)
		AG	66	51
		AA	5	6
CLEC7A	rs16910631	CC	153	139	C, T	327, 23	294, 20	0.8078 (0.7024)	0.9056 (0.8662)	0.9269 (0.6045)	1.0000 (1.0000)
		CT	21	16
		TT	1	2
NOD2	rs2066844 (SNP8)	CC	146	148	C, T	319, 31	305, 9	0.0498 (0.0065)	0.0219 (0.0019)	0.9583 (0.5000)	0.0368 (0.0016)
		CT	27	9
		TT	2	0
NOD2	rs2066845 (SNP12)	GG	163	149	G, C	338, 12	306, 8	0.8481 (0.6453)	0.8481 (0.6453)	NA	0.7874 (0.6505)
		GC	12	8
		CC	0	0
NOD2	rs2066847 (SNP13)	C-C	147	143	C, CC	316, 34	300, 14	0.0923 (0.0321)	0.1569 (0.0682)	0.1025 (0.0312)	0.0474 (0.0103)
		C-CC	22	14
		CC-CC	6	0

¹Italic: Minor allele according to database https://www.ncbi.nlm.nih.gov/snp/.

²Numbers in brackets refer to the P value prior to Benjamini-Hochberg correction (23 tests); significant differences (P < 0.05) are indicated in bold.

³Refers to the minor allele. SNP: Single nucleotide polymorphism; NA: Not applicable (due to the absence of CC genotype).