Copyright
©The Author(s) 2020.
World J Gastroenterol. Apr 28, 2020; 26(16): 1926-1937
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1926
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1926
Table 6 Prediction of amino acid evolutionary conservation due to mutations in MSH6 and other genes
| Case No. | Gene | GERP++ | phyloP | ||
| Score | Prediction | Score | Prediction | ||
| 3 | MUTYH | 5.67 | Conserved | 6.955 | Conserved |
| 3 | MLH1 | 5.67 | Conserved | 7.336 | Conserved |
| 3 | PMS2 | -3.23 | Nonconserved | -0.25 | Nonconserved |
| 4 | MSH6 | 5.5 | Conserved | 7.481 | Conserved |
| 4 | MLH1 | 5.67 | Conserved | 7.336 | Conserved |
| 4 | PMS2 | -3.23 | Nonconserved | -0.25 | Nonconserved |
| 7 | MLH3 | 4.6 | Conserved | 5.502 | Conserved |
| 7 | AXIN2 | 2.07 | Conserved | 2.225 | Conserved |
| 9 | MSH6 | 5.23 | Conserved | 8.923 | Conserved |
| 9 | APC | 6.02 | Conserved | 3.925 | Conserved |
| 10 | MSH2 | -1.25 | Nonconserved | 1.857 | Nonconserved |
| 10 | MSH6 | / | / | / | / |
| 10 | APC | 5.92 | Conserved | 8.947 | Conserved |
| 14 | MSH2 | 3.94 | Conserved | 3.331 | Conserved |
| 14 | MSH2 | / | / | / | / |
| 14 | PMS1 | 4.99 | Conserved | 7.805 | Conserved |
| 14 | PMS1 | 2.11 | Conserved | 4.333 | Conserved |
| 15 | PTEN | / | / | / | / |
| 19 | MSH2 | 4.62 | Conserved | 1.611 | Nonconserved |
| 20 | MLH1 | 5.76 | Conserved | 2.993 | Conserved |
- Citation: Zhang Z, Duan FX, Gu GL, Yu PF. Mutation analysis of related genes in hamartoma polyp tissue of Peutz-Jeghers syndrome. World J Gastroenterol 2020; 26(16): 1926-1937
- URL: https://www.wjgnet.com/1007-9327/full/v26/i16/1926.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i16.1926