Basic Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Apr 28, 2020; 26(16): 1926-1937
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1926
Table 3 Prediction of protein function and amino acid evolution conservation of LKB1/STK11
Case No.Polyphen-2
Mutation taster
FATHMM
M-CAP
GERP++
phyloP
ScorePredictionScorePredictionScorePredictionScorePredictionScorePredictionScorePrediction
11Probably damaging1Pathogenic-2.5Damaging0.591Damaging5.6Conserved7.91Conserved
2//1Pathogenic////3.9Conserved8.998Conserved
3//1Pathogenic////////
4//1Pathogenic////////
5//1Pathogenic////////
60.993Probably damaging1Pathogenic-2.79Damaging0.704Damaging5.6Conserved7.799Conserved
7//1Pathogenic////////
8////////////
10////////////
13//1Pathogenic////////
14//1Pathogenic////3.9Conserved8.998Conserved
16//1Pathogenic////////
17////////////
18//1Pathogenic////3.9Conserved3.875Conserved
19//1Pathogenic////////
20////////////