Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer

doi:10.3748/wjg.v26.i16.1912

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2020; 26(16): 1912-1925
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1912

Table 5 Serum levels of anti and pro-inflammatory cytokines in inflammatory bowel disease patients compared to early and advanced colorectal cancer cases

Cytokines	IBD	Early CRC	P value (U-test), IBD vs early CRC	Advanced CRC	P value (U-test), IBD vs advanced CRC
TGFB1 (ng/mL)	11.19 (9.36-20.99)	22.74 (18.17-27.98)	0.001344	21.51 (15.5-31.05)	0.0031
IL-10 (pg/mL)	0.4 (0.0-2.8)	7.73 (6.0-12.71)	0.000006	8.84 (7.2-19.81)	0.000002
IL-6 (pg/mL)	0.0 (0.0-2.7)	3.06 (2.03-4.19)	0.0153	4.19 (2.15-8.4)	0.044
IL-23A (pg/mL)	0.7 (0.0-3.7)	25.7 (24.6-32.5)	0.000024	30.5 (26.3-33.5)	0.000009
IL-17A (pg/mL)	0.0 (0.0-0.26)	3.62 (0.0-8.23)	0.0086	1.2 (0.0-12.08)	0.178

The results are presented as median (IQR, 25%-75% percentile). IBD: Inflammatory bowel disease; CRC: Colorectal cancer.

Citation: Velikova TV, Miteva L, Stanilov N, Spassova Z, Stanilova SA. Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer. World J Gastroenterol 2020; 26(16): 1912-1925
URL: https://www.wjgnet.com/1007-9327/full/v26/i16/1912.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i16.1912