Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer

Table 3 The local gene expression in inflammatory bowel disease patients compared to that in advanced colorectal cancer cases

Genes	IBD			Advanced stages CRC (3 + 4)			P value IBD vs Advanced CRC
	dCt ± SD		RQ (min-max)	dCt ± SD		RQ (min-max)
	Inflamed tissue	Non-inflamed tissue		Tumoral tissue	Non-tumoral tissue
Foxp3	14.94 ± 2.65	15.81 ± 2.59	1.82 (0.11-74.85)	19.71 ± 5.2	21.89 ± 4.2	4.55 (0.45-45.1)	0.101
TGFB1	9.52 ± 4.13	8.97 ± 4.4	0.68 (0.03-2.27)	17.46 ± 3.3	18.5 ± 1.6	2.05 (0.211-14.56)	0.176
IL-10	16.87 ± 1.76	17.7 ± 1.5	1.78 (0.22-28.5)	16.69 ± 6.2	19.09 ± 5	5.26 (0.43-158.8)	0.113
IL-6	17.13 ± 3.05	19.53 ± 2.7	5.28 (0.27-61.6)	19.78 ± 3.1	21.39 ± 2.8	3.05 (0.025-434.7)	0.608
IL-23A	18.0 ± 2.09	18.1 ± 2.8	1.07 (0.07-6.61)	13.64 ± 2.1	17.44 ± 2.4	13.96 (3.93-36.28)	0.012
IL-17A	18.9 ± 2.65	20.3 ± 2.9	2.70 (0.07-20.5)	26.62 ± 3.9	26.73 ± 3.2	1.07 (0.034-89.26)	0.350

The results are presented as dCt ± SD and RQ (min-max). IBD: Inflammatory bowel disease; CRC: Colorectal cancer; dCt: Normalized to the endogenous control; RQ: Relative quantity of mRNA levels.