Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer

Table 2 The local gene expression in inflammatory bowel disease patients compared to that in early colorectal cancer cases

Genes	IBD			Early stages CRC (1 + 2)			P value IBD vs Early CRC
	dCt ± SD		RQ (min-max)	dCt ± SD		RQ (min-max)
	Inflamed tissue	Non-inflamed tissue		Tumoral tissue	Non-tumoral tissue
Foxp3	14.94 ± 2.65	15.81 ± 2.59	1.82 (0.11-74.85)	16.98 ± 5.8	20.41 ± 4.5	10.74 (0.615-97.2)	0.023
TGFB1	9.52 ± 4.13	8.97 ± 4.4	0.68 (0.03-2.27)	16.99 ± 2.4	18.83 ± 2.3	3.59 (0.222-93.7)	0.057
IL-10	16.87 ± 1.76	17.7 ± 1.5	1.78 (0.22-28.5)	16.17 ± 5	19.25 ± 4.1	8.44 (1.253-202.3)	0.019
IL-6	17.13 ± 3.05	19.53 ± 2.7	5.28 (0.27-61.6)	18.12 ± 4.7	20.59 ± 1.9	5.55 (0.03-512.4)	0.97
IL-23A	18.0 ± 2.09	18.1 ± 2.8	1.07 (0.07-6.61)	11.69 ± 1.9	17.65 ± 2.9	61.93 (2.04-219.5)	0.001
IL-17A	18.9 ± 2.65	20.3 ± 2.9	2.70 (0.07-20.5)	22.42 ± 3.6	27.17 ± 2.9	26.83 (2.73-494.9)	0.029

The results are presented as dCt ± SD and RQ (min-max). IBD: Inflammatory bowel disease; CRC: Colorectal cancer; dCt: Normalized to the endogenous control; RQ: Relative quantity of mRNA levels.