Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer

Table 1 Local gene expression of pro and anti-inflammatory cytokines in paired inflamed vs non-inflamed tissues of inflammatory bowel disease patients and paired tumoral vs adjacent non-tumoral mucosa of colorectal cancer patients

Genes	IBD			CRC			P value IBD vs CRC
	dCt ± SD		RQ (min-max)	dCt ± SD		RQ (min-max)
	Inflamed tissue	Non-inflamed tissue		Tumoral tissue	Non-tumoral tissue
Foxp3	14.94 ± 2.65	15.81 ± 2.59	1.82 (0.11-74.85)	18.62 ± 5.5	21.30 ± 4.3	6.42 (0.47-97.2)	0.025
TGFB1	9.52 ± 4.13	8.97 ± 4.4	0.68 (0.03-2.27)	17.27 ± 2.9	18.63 ± 1.9	2.37 (0.211-93.7)	0.007
IL-10	16.87 ± 1.76	17.7 ± 1.5	1.78 (0.22-28.5)	16.43 ± 5.5	19.17 ± 4.4	6.66 (0.43-202.3)	0.023
IL-6	17.13 ± 3.05	19.53 ± 2.7	5.28 (0.27-61.6)	19.11 ± 3.8	21.07 ± 2.5	3.88 (0.03-512.4)	0.784
IL-23A	18.0 ± 2.09	18.1 ± 2.8	1.07 (0.07-6.61)	12.56 ± 2.1	17.55 ± 2.5	28.5 (2.04-219.5)	0.0003
IL-17A	18.9 ± 2.65	20.3 ± 2.9	2.70 (0.07-20.5)	24.7 ± 4.3	26.9 ± 3.0	4.69 (0.034-494.9)	0.574

The results are presented as dCt ± SD and RQ (min-max). IBD: Inflammatory bowel disease; CRC: Colorectal cancer; dCt: Normalized to the endogenous control; RQ: Relative quantity of mRNA levels.