Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin and its regulation of microRNA-137

Figure 5 Influence of microRNA-137 on colon cancer cell resistance to oxaliplatin. A: Determined miR-137 expression in constructed drug-resistant cell lines; B: Influence of oxaliplatin (L-OHP) at different concentrations on growth inhibition of HCT116/L-OHP cells in each group after transfection; C: Effects of L-OHP at different concentrations on growth inhibition of SW480/L-OHP cells in each group after transfection; D: Comparison of apoptosis rate of drug-resistant cells among different groups after transfection and apoptosis map; E: Comparison of apoptotic protein of drug-resistant cells among different groups after transfection and apoptotic protein map. SW480/L-OHP indicates SW480 cell line with L-OHP resistance. HCT116/L-OHP indicates HCT116 cell line with resistance L-OHP resistance. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 for between-group comparisons. L-OHP: Oxaliplatin; miR-NC: MiR negative control; OIP5-AS1: Opa-interacting protein 5 antisense RNA 1.