Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin and its regulation of microRNA-137

Figure 3 Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin. A: Determined Opa-interacting protein 5 antisense RNA 1 expression in constructed drug-resistant cell lines; B: Effects of oxaliplatin (L-OHP) at different concentrations on growth inhibition of HCT116 and HCT116/L-OHP cells; C: Effects of L-OHP at different concentrations on growth inhibition of SW480 and SW480/L-OHP cells; D: Effects of L-OHP at different concentrations on growth inhibition of HCT116/L-OHP cells in each group after transfection; E: Influence of L-OHP at different concentrations on growth inhibition of SW480/L-OHP cells in each group after transfection; F: Comparison of apoptosis rate of drug-resistant cells among different groups after transfection and apoptosis map; G: Comparison of drug-resistant cell apoptosis among different groups after transfection and apoptotic protein map. SW480/L-OHP indicates SW480 cell line with L-OHP resistance. HCT116/L-OHP indicates HCT116 cell line with L-OHP resistance. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 for between-group comparisons. OIP5-AS1: Opa-interacting protein 5 antisense RNA 1; L-OHP: Oxaliplatin.