Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population

doi:10.3748/wjg.v26.i12.1329

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2020; 26(12): 1329-1339
Published online Mar 28, 2020. doi: 10.3748/wjg.v26.i12.1329

Table 1 Candidate single-nucleotide polymorphisms selected from whole-exome sequencing of 8 Polygonum multiflorum-induced liver injury patients and 8 healthy controls

SNP ID	Chromosome	Gene	Number of PM-DILI patients with candidate SNP	Number of healthy controls with candidate SNP
rs1042597	2	UGT1A8	6	0
rs3795958³	2	DRC1	6	3
rs111686806	6	HLA-A	5	0
rs2231119	6	HLA-A	8	0
rs1136903³	6	HLA-A	6	0
rs115662401³	6	HLA-A	6	0
rs117162979³	6	HLA-A	5	2
rs1059516³	6	HLA-A	5	0
rs1050341²	6	HLA-B	5	0
rs1055348	6	HLA-B	5	0
rs2308655³	6	HLA-B	6	0
rs1050458¹	6	HLA-B	5	0
rs1051488¹	6	HLA-B	6	0
rs202047044	6	HLA-DRB1	4	0
rs111534875	6	HLA-DRB1	5	3
rs78246137	6	HLA-DRB1	7	0
rs2308768³	6	HLA-DRB1	5	0
rs1799931³	8	NAT2	4	0
rs5747933	22	PRODH	7	3

¹Single-nucleotide polymorphism (SNPs) detected in fewer than 95% of individuals (2 SNPs).

²SNPs with minor allele frequency < 5% (1 SNPs).

³SNPs with Hardy-Weinberg equilibrium test P values < 0.05 (8 SNPs). PM-DILI: Polygonum multiflorum-induced liver injury.

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Citation: Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L, Wang SY, Liu XZ, Tan KA, Shi WW, Wang GQ, Hou FQ. Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population. World J Gastroenterol 2020; 26(12): 1329-1339
URL: https://www.wjgnet.com/1007-9327/full/v26/i12/1329.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i12.1329

Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L, Wang SY, Liu XZ, Tan KA, Shi WW, Wang GQ, Hou FQ. Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population. World J Gastroenterol 2020; 26(12): 1329-1339 [PMID: 32256020 DOI: 10.3748/wjg.v26.i12.1329]

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