Diagnosing coeliac disease: Out with the old and in with the new?

Figure 1 Current diagnostic pathway for suspected coeliac disease. Currently, serology forms the front line of testing for patients currently on a diet containing gluten whilst genotyping can be used for patients who aren’t consuming gluten. Histopathology is currently the most conclusive test for the presence of the condition, even though diagnosis can be difficult for patients with mild or equivocal pathology. CD: Coeliac disease; tTG: Tissue transglutaminase; DGP: Deamidated gliadin peptides.