Liver stem cells: Plasticity of the liver epithelium

Figure 1 Schematic summarising potential non-hepatocyte sources of regeneration. Lineage-tracing models using Cre recombinase controlled under a cholangiocyte-specific promoter have shown cholangiocytes giving rise to hepatocytes. Alternatively, Sox9+ hybrid hepatocytes have been shown to give rise to both cholangiocytes and hepatocytes.