Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review

Table 16 Individual studies included for surgeries related to ulcerative colitis

Study	Country	Intervention	Comparator	Study design	Follow-up	n	Colectomy
Schmidt et al[30]	Germany	Tacrolimus	-	Retrospective cohort	24 mo	58	22%
		Tacrolimus with purine analogues	-	Retrospective cohort	24 mo	79	18%
Llaó et al[31]	Spain	IV corticosteroids	-	Retrospective cohort	7 d	110	15%
Moskovitz et al[34]	Belgium	Cyclosporine	-	Retrospective cohort	9.3 d	142	16.9%
		Cyclosporine	-	Retrospective cohort	1 yr	N/A	37%
		Cyclosporine	-	Retrospective cohort	4 yr	N/A	59%
		Cyclosporine	-	Retrospective cohort	6 yr	N/A	84%
		Cyclosporine	-	Retrospective cohort	7 yr	N/A	88%
Campbell et al[35]	UK	Cyclosporine	-	Retrospective cohort	7 yr		58%
Arts et al[36]	Belgium	Cyclosporine	-	Retrospective cohort	9 d	86	16.3%
		Cyclosporine	-	Retrospective cohort	1 yr	45	36%
		Cyclosporine	-	Retrospective cohort	3 yr	13	45%
Yamamoto et al[38]	Japan	Tacrolimus	Anti-TNF	Retrospective	12 wk	100	10% (tacrolimus); 16% (anti-TNF); P = 0.55
Cheifetz et al[40]	United States	Cyclosporine		Retrospective cohort	4 wk	71	15%
		Cyclosporine		Retrospective cohort	1 yr	71	39%
		Cyclosporine		Retrospective cohort	2 yr	71	42%
		Cyclosporine		Retrospective cohort	5 yr	71	46%
Gustavsson et al[49]	Sweden	Corticosteroid		Retrospective cohort	3 mo	45 (moderate)	8.9%
		Corticosteroid		Retrospective cohort	3 mo	61 (severe)	45.9%
		Corticosteroid		Retrospective cohort	20 yr	41 (moderate)	48.8%
		Corticosteroid		Retrospective cohort	20 yr	33 (severe)	33.3%
Van Assche et al[48]	Belgium	Cyclosporine 4 mg/kg	Cyclosporine 2 mg/kg	RCT	2 wk	73	13.1% (4 mg/kg); 8.6% (2 mg/kg)
Hyde et al[44]	United Kingdom	Hydrocortisone	-	Retrospective cohort	5 d	216	15.7%
		Cyclosporine	-	Retrospective cohort	19 mo	50	16%
Kjeldsen et al[43]	Denmark	Prednisolone	-	Retrospective cohort	8 mo	51	42% (severe disease); 13% (moderate disease)

IV: Intravenous; n: Number of patients; N/A: Not available; RCT: Randomized clinical trial; TNF: Tumor necrosis factor.