Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells

Table 1 Gene ontology enrichment results of differentially expressed genes

GO	Count	P-value	Description
Enriched GO biological process of DEGs
GO:0007165	52	0.001	Signal transduction
GO:0006508	24	0.015	Proteolysis
GO:0008283	18	0.03	Cell proliferation
GO:0070374	13	0.004	Positive regulation of ERK1 and ERK2 cascade
GO:0001666	12	0.009	Response to hypoxia
GO:0018108	10	0.029	Peptidyl-tyrosine phosphorylation
GO:0001501	9	0.04	Skeletal system development
GO:0050907	8	0.018	Detection of chemical stimulus involved in sensory perception
GO:0002576	8	0.026	Platelet degranulation
GO:0006302	7	0.011	Double-strand break repair
GO:0050731	7	0.028	Positive regulation of peptidyl-tyrosine phosphorylation
GO:0097191	6	0.006	Extrinsic apoptotic signaling pathway
GO:0007269	6	0.014	Neurotransmitter secretion
GO:0043406	6	0.025	Positive regulation of MAP kinase activity
Enriched GO chemical component of DEGs
GO:0005886	148	0.000	Plasma membrane
GO:0005887	66	0.000	Integral component of plasma membrane
GO:0005576	59	0.027	Extracellular region
GO:0009897	13	0.017	External side of plasma membrane
GO:0005604	7	0.023	Basement membrane
GO:0098793	6	0.033	Presynapse
Enriched GO molecular function of DEGs
GO:0042802	33	0.010	Identical protein binding
GO:0005509	32	0.009	Calcium ion binding
GO:0004888	14	0.007	Transmembrane signaling receptor activity
GO:0005516	12	0.016	Calmodulin binding
GO:0005215	12	0.025	Transporter activity
GO:0004222	9	0.013	Metalloendopeptidase activity
GO:0004713	9	0.031	Protein tyrosine kinase activity
GO:0008237	8	0.007	Metallopeptidase activity
GO:0002020	8	0.022	Protease binding
GO:0003707	6	0.019	Steroid hormone receptor activity
GO:0008236	6	0.030	Serine-type peptidase activity
GO:0003705	6	0.036	Transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001540	5	0.014	Hormone binding
GO:0001206	4	0.002	Peptidoglycan binding

GO: Gene ontology; DEGs: Differentially expressed genes.