Two-year delay in ulcerative colitis diagnosis is associated with anti-tumor necrosis factor alpha use

doi:10.3748/wjg.v25.i8.989

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Retrospective Study

World J Gastroenterol. Feb 28, 2019; 25(8): 989-1001
Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.989

Table 1 Baseline characteristics of patients (n = 551)

Characteristics	Value
Male sex (%)	318/551 (55.7)
Age at diagnosis, yr	40.56 ± 16.11
BMI at diagnosis, kg/m²	22.28 ± 3.19
Family history of IBD (%)	51/369 (13.8)
History of smoking (%)	77/443 (17.4)
First symptom
Hematochezia	388/548 (70.8)
Diarrhea	164/548 (29.9)
Abdominal pain	39/548 (7.1)
Diagnostic interval, d (median)	223.28 ± 483.15 (69)
Time from first symptom to hospital visit, d (median)	154.22 ± 379.140 (40)
Time from first hospital visit to diagnosis, d (median)	69.06 ± 295.04 (9)
Mayo score at diagnosis (%)
Mild	179/399 (44.9)
Moderate	204/399 (51.1)
Severe	220/399 (4.0)
Disease extent at diagnosis (%)
Proctitis	253/547 (46.3)
Left side	160/547 (29.3)
Extensive	134/547 (24.5)
Steroid (oral or intravenous) use (%)	250/551 (45.4)
AZA/6MP use (%)	163/551 (29.6)
Anti-TNFα use (%)	50/551 (9.1)
Admission due to flare-up (%)	121/430 (22.0)
Frequent admission due to flare-up (%)	50/551 (9.1)
UC-related surgery (%)	7/551 (1.3)
Clinical remission at the latest follow-up (%)	333/467 (71.3)

BMI: Body mass index; IBD: Inflammatory bowel disease; AZA/6MP: Azathioprine or 6-mercaptopurine; Anti-TNFα: Anti-tumor necrosis factor alpha; UC: Ulcerative colitis.

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Citation: Kang HS, Koo JS, Lee KM, Kim DB, Lee JM, Kim YJ, Yoon H, Jang HJ. Two-year delay in ulcerative colitis diagnosis is associated with anti-tumor necrosis factor alpha use. World J Gastroenterol 2019; 25(8): 989-1001
URL: https://www.wjgnet.com/1007-9327/full/v25/i8/989.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i8.989

Kang HS, Koo JS, Lee KM, Kim DB, Lee JM, Kim YJ, Yoon H, Jang HJ. Two-year delay in ulcerative colitis diagnosis is associated with anti-tumor necrosis factor alpha use. World J Gastroenterol 2019; 25(8): 989-1001 [PMID: 30833804 DOI: 10.3748/wjg.v25.i8.989]

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