Triggers of histologically suspected drug-induced colitis

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 28, 2019; 25(8): 967-979
Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.967

Table 3 Histopathological reassessment n (%)

Parameter (n = 28)	Drug-induced colitis without atherosclerosis	Drug-induced colitis with atherosclerosis	Ischaemiccolitis
Oedema	2 (7.1)	2 (7.1)	4 (14.3)
Haemorrhage	1 (3.6)^a²	8 (28.6)^a¹	6 (21.4)
Lymphocytic infiltration	27 (96.4)	27 (96.4)	27 (96.4)
Granulocytic infiltration	27 (96.4)	26 (92.9)	28 (100.0)
Eosinophilic infiltration	12 (42.9)^b²	7 (25.0)	1 (3.6)^a³
Erosions	2 (7.1)^b²	9 (32.1)^a¹	10 (35.7)
Ulcerous lesions	4 (14.3)^b²	3 (10.7)	16 (57.1)^b³
Necrosis	1 (3.6)^b²	1 (3.6)	16 (57.1)^b³
Fibrin plaques on erosions	2 (7.1)	2 (7.1)	3 (10.7)
Fibrosis	3 (10.7)	3 (10.7)	7 (25.0)

¹Drug-induced colitis without atherosclerosis vs drug-induced colitis with atherosclerosis.

²Drug-induced colitis without atherosclerosis vs ischaemic colitis.

³Drug-induced colitis with atherosclerosis vs ischaemic colitis.

^aP < 0.05.

^bP < 0.01.

Statistical analysis was carried out with χ² test.

Citation: Brechmann T, Günther K, Neid M, Schmiegel W, Tannapfel A. Triggers of histologically suspected drug-induced colitis. World J Gastroenterol 2019; 25(8): 967-979
URL: https://www.wjgnet.com/1007-9327/full/v25/i8/967.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i8.967

Brechmann T, Günther K, Neid M, Schmiegel W, Tannapfel A. Triggers of histologically suspected drug-induced colitis. World J Gastroenterol 2019; 25(8): 967-979 [PMID: 30833802 DOI: 10.3748/wjg.v25.i8.967]

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