Triggers of histologically suspected drug-induced colitis

doi:10.3748/wjg.v25.i8.967

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Feb 28, 2019 (publication date) through May 9, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2019; 25(8): 967-979
Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.967

Table 2 Comorbidities n (%)

Comorbidity	Drug-induced colitis, n = 211	Non-inflammatory controls, n = 211	Inflammatory controls, n = 211
Pulmonary	39 (18.5)	31 (14.7)	37 (17.5)
Cardiac	110 (52.1)	93 (44.1)	87 (41.2)
Neurological	27 (12.8)	23 (10.9)	19 (9.0)
Psychiatric	10 (4.7)	9 (4.3)	10 (4.7)
Endocrine	47 (22.3)	44 (20.9)	30 (14.2)
Renal	28 (13.2)	18 (8.5)	21 (10.0)
Hepatic	11 (5.2)	13 (6.2)	11 (5.2)
Oncological	14 (6.6)	25 (11.8)	17 (8.1)
Other	19 (9.0)	15 (7.1)	16 (7.6)
Heart failure	35 (16.6)	16 (7.6)^b²	31 (14.7)^a³
Renal insufficiency	24 (11.4)	14 (6.6)	18 (8.5)
Atrial fibrillation	26 (12.3)	18 (8.5)	22 (10.4)
Coronary heart disease	47 (22.3)	28 (13.3)^a²	35 (16.6)
Peripheral arterial occlusive disease	7 (3.3)	10 (4.7)	11 (5.2)
Atherosclerosis	74 (35.1)^b¹	39 (18.5)^b²	40 (19.0)
Arterial hypertension	98 (46.4)	97 (46.0)	87 (41.2)
Diabetes mellitus	46 (21.8)	45 (21.3)	32 (15.2)
Hypercholesterinaemia	20 (9.5)	16 (7.6)	18 (8.5)
Hyperlipoproteinaemia	22 (10.4)^a¹	11 (5.2)^a²	9 (4.3)
Chronic obstructive lung disease	29 (13.7)	24 (11.4)	27 (12.8)
Stroke	14 (6.6)	9 (4.3)	11 (5.2)
Smoking	77 (36.7)	66 (31.3)	78 (37.0)
Surgery	9 (4.3)	1 (0.5)^a²	3 (1.4)
Intensive care therapy	9 (4.3)	2 (0.9)^a²	4 (3.1)

¹Drug-induced colitis vs inflammatory controls.

²Drug-induced colitis vs non-inflammatory controls.

³Non-inflammatory controls vs inflammatory controls.

^aP < 0.05.

^bP < 0.01.

Statistical analysis was carried out with χ² test.

Citation: Brechmann T, Günther K, Neid M, Schmiegel W, Tannapfel A. Triggers of histologically suspected drug-induced colitis. World J Gastroenterol 2019; 25(8): 967-979
URL: https://www.wjgnet.com/1007-9327/full/v25/i8/967.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i8.967