Triggers of histologically suspected drug-induced colitis

Table 1 Basic demographic characteristics n (%)

	Drug-induced colitis, n = 211	Non-inflammatory controls, n = 211	Inflammatory controls, n = 211
Basic characteristics
Age (yr)	62.3 ± 16.4	62.2 ± 16.3	61.8 ±15.7
Gender (male)	97 (46.0)	97 (46.0)	97 (46.0)
Height (cm)	168.9 ± 9.5	168.3 ± 12.4	170.0 ± 9.3
Body weight (kg)	76.9 ± 22.6	75.0 ± 20.3	72.9 ± 19.7
BMI (kg/m2)	26.9 ± 7.2a1b	26.3 ± 6.8	25.0 ± 5.6a3
ASAb2
ASA 1	0 (0)	3 (1.4)	0 (0)
ASA 2	133 (63.0)	169 (80.1)	155 (73.5)
ASA 3	70 (33.2)	37 (17.5)	52 (24.6)
ASA 4	8 (3.8)	2 (0.9)	4 (1.9)
ECOGb2,b3
ECOG 0	0 (0)	1 (0.5)	2 (0.9)
ECOG 1	8 (3.8)	75 (35.5)	13 (6.2)
ECOG 2	149 (70.6)	104 (49.3)	147 (69.7)
ECOG 3	41 (19.4)	26 (12.3)	43 (20.4)
ECOG 4	13 (6.2)	5 (2.4)	6 (2.8)
Indication of colonoscopyb1,a2
Diarrhoea	73 (34.6)	95 (45.0)	97 (46.0)
Constipation	6 (2.8)	5 (2.4)	1 (0.5)
Gastrointestinal bleeding	63 (29.9)	31 (14.6)	36 (17.1)
Abdominal pain	47 (22.3)	54 (25.6)	46 (21.8)
Weight loss	6 (2.8)	5 (2.4)	4 (1.9)
Scheduled survey	2 (0.9)	1 (0.5)	2 (0.9)
Miscellaneous	14 (6.6)	20 (9.5)	25 (11.8)

¹Drug-induced colitis vs inflammatory controls.

²Drug-induced colitis vs non-inflammatory controls.

³Non-inflammatory controls vs inflammatory controls.

^aP < 0.05.

^bP < 0.01. Statistical analysis was carried out with χ² test, ANOVA or t-test as appropriate. BMI: Body mass index.