Diagnostic and prognostic value of lncRNA cancer susceptibility candidate 9 in hepatocellular carcinoma

Table 6 The top10 Kyoto Encyclopedia of Genes and Genomes signal pathways

Term	Count	P value	Genes
MicroRNAs in cancer	7	0.002	KIF23, CCNE1, MAP2K1, WNT3A, PIM1, HMGA2, CDC25A
Pathways in cancer	8	0.005	CCNE1, RET, MAP2K1, WNT3A, ITGA2, LAMC1, AXIN2, PLCB1
p53 signaling pathway	4	0.007	STEAP3, CCNE1, SERPINE1, CHEK1
Chagas disease (American trypanosomiasis)	4	0.024	GNAL, IRAK1, SERPINE1, PLCB1
Proteoglycans in cancer	5	0.024	MAP2K1, WNT3A, ESR1, ITGA2, TWIST1
Cell cycle	4	0.030	CCNE1, CHEK1, WEE1, CDC25A
PI3K-Akt signaling pathway	6	0.038	CCNE1, SGK1, MAP2K1, ITGA2, LAMC1, ANGPT2
Hippo signaling pathway	4	0.048	WNT3A, SERPINE1, AXIN2, SNAI2
Small cell lung cancer	3	0.081	CCNE1, ITGA2, LAMC1
Progesterone-mediated oocyte maturation	3	0.082	MAP2K1, CPEB3, CDC25A

KIF23: Kinesin family member 23; CCNE1: Cyclin E1; MAP2K1: Mitogen-activated protein kinase kinase 1; WNT3A: Wnt family member 3A; PIM1: Pim-1 proto-oncogene, serine/threonine kinase; HMGA2: High mobility group AT-hook 2; CDC25A: Cell division cycle 25A; RET: Ret proto-oncogene; ITGA2: Integrin subunit alpha 2; LAMC1: Laminin subunit gamma 1; AXIN2: Axin 2; PLCB1: Phospholipase C beta 1; STEAP3: STEAP3 metalloreductase; SERPINE1: Serpin family E member 1; CHEK1: Checkpoint kinase 1; CPEB3: Cytoplasmic polyadenylation element binding protein 3; SGK1: Serum/glucocorticoid regulated kinase 1; ANGPT2: Angiopoietin 2; WEE1: WEE1 G2 checkpoint kinase; ESR1: Estrogen receptor 1; TWIST1: Twist family bHLH transcription factor 1; GNAL: G protein subunit alpha L; IRAK1: Interleukin 1 receptor associated kinase 1; SNAI2: Snail family transcriptional repressor 2.