Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

Table 7 Correlation of bowel disease questionnaire scores with isovalerate or isohexanoate

Groups	Metabolites	Frequency of abdominal pain		Severity of abdominal pain
		r	P value	r	P value
IBS-D	Isovalerate	0.4752	0.008	0.3771	0.040
	Isohexanoate	0.4141	0.023	0.097	0.612
All subjects	Isovalerate	0.200	0.188	0.143	0.350
	Isohexanoate	0.4732	0.001	0.3711	0.012

¹There was association between parameters (P < 0.05).

²There was association between parameters (P < 0.01). IBS-D: Irritable bowel syndrome with predominant diarrhea.