Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i43.6416

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2019; 25(43): 6416-6429
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6416

Table 6 Multiple linear regression model for maximum tolerable threshold

Groups	Metabolites	Unstandardized coefficients		Standar-dized coeffici-ents β	t	P value	Collinearity statistics
Groups	Metabolites	b	SE	Standar-dized coeffici-ents β	t	P value	Tolerance	VIF
IBS-D	Isovalerate²	5.451	1.824	1.525	2.989	0.006	0.099	10.132
IBS-D	Valerate¹	-2.171	0.946	-1.171	-2.295	0.030	0.099	10.132
All subjects	Isohexanoate¹	-40.910	18.695	-0.317	-2.188	0.034	NA	NA

¹Metabolite which was correlated with maximum tolerable threshold (P < 0.05).

²Metabolite which was correlated with maximum tolerable threshold (P < 0.01); SE: Standard error; VIF: Variance inflation factor; IBS-D: Irritable bowel syndrome with predominant diarrhea; NA: Not applicable.

Citation: Zhang WX, Zhang Y, Qin G, Li KM, Wei W, Li SY, Yao SK. Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(43): 6416-6429
URL: https://www.wjgnet.com/1007-9327/full/v25/i43/6416.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i43.6416