Changes of gastric ulcer bleeding in the metropolitan area of Japan

doi:10.3748/wjg.v25.i42.6342

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Nov 14, 2019; 25(42): 6342-6353
Published online Nov 14, 2019. doi: 10.3748/wjg.v25.i42.6342

Table 1 Patient demographics

	All patients	H. pylori-positive	H. pylori-negative	P value	Anticoagulants/antiplatelet drug/NSAIDs	No drugs	P value
Total	564	340	115		219	345
Male/female	343/221	223/117	66/49	0.11¹	127/92	216/129	0.27¹
Age (mean ± SD)	70.2 ± 14.3	66.6 ± 13.6	72.3 ± 14.3	< 0.01²	77.1 ± 10.3	65.8 ± 14.7	< 0.01²
H. pylori status
Positive	340 (60.3)	-	-		104 (47.5)	236 (68.4)	< 0.01¹
Negative	115 (20.4)	-	-		56 (25.6)	59 (17.1)
Unknown	109 (19.3)	-	-		59 (26.9)	50 (14.5)
Toxic agents
Anticoagulants/antiplatelets/NSAIDs	219 (38.8)	104 (30.6)	56 (48.7)	< 0.01¹	219 (100)	0
Anticoagulants	43 (7.6)	19 (5.6)	12 (10.4)		43 (19.6)	0
Antiplatelets	130 (23.0)	60 (17.6)	33 (28.7)		130 (59.4)	0
NSAIDs	174 (30.9)	85 (25.0)	39 (33.9)		174 (79.5)	0
Two or more drugs	76 (13.5)	50 (14.7)	26 (22.6)		(50.7)	0
None	345 (61.2)	236 (69.4)	59 (51.3)		0	345 (100)
Single or multiple
Single	400 (70.9)	251 (73.8)	71 (61.7)	0.02¹	138 (63.0)	254 (73.6)	0.01¹
Multiple	108 (29.1)	89 (26.2)	44 (38.3)		81 (37.0)	91 (26.4)
Location (single ulcer)
U	127 (22.5)	80 (23.5)	15 (13.0)	< 0.01³	47 (21.5)	76 (22.0)	0.17³
M	216 (38.3)	151 (44.4)	26 (22.6)		66 (30.1)	143 (41.4)
L	57 (10.1)	18 (5.3)	30 (26.1)		25 (11.4)	32 (9.3)
Forrest Classification				0.10³			< 0.01³
Ia	25 (4.4)	14 (4.1)	5 (4.3)		11 (5.0)	14 (4.1)
Ib	44 (7.8)	18 (5.3)	11 (9.6)		24 (11.0)	20 (5.8)
IIa	280 (49.6)	188 (55.3)	46 (40.0)		91 (41.6)	189 (54.8)
IIb	32 (5.7)	16 (4.7)	7 (6.1)		21 (9.6)	11 (3.2)
IIc	73 (12.9)	42 (12.4)	17 (14.8)		28 (12.8)	45 (13.0)
III	110 (19.5)	62 (18.2)	29 (25.2)		44 (20.1)	66 (19.1)
Previous antacids	86 (15.3)	35 (10.3)	28(24.4)	< 0.01¹	41 (18.7)	46 (13.3)	0.63¹
PPIs	37 (6.6)	7 (2.1)	17(14.8)		18 (8.2)	19 (5.5)
H₂ blockers	49 (8.7)	28 (8.2)	11 (9.6)		23 (10.5)	26 (7.5)
P-CAB	1 (0.2)	028 (8.2)	011 (9.6)		023 (10.5)	1 (0.3)
None	477 (84.6)	305 (89.7)	87 (75.7)		178 (81.3)	299 (86.7)

¹Fisher’s exact test.

²Student’s t-test.

³Pearson’s Chi-squared test. SD: Standard deviation; H. pylori: Helicobacter pylori; U: Upper; M: Middle; L: Lower; PPIs: Proton pump inhibitors; H2 blockers: Histamine type 2 receptor blockers; P-CAB: Potassium-competitive acid blocker; NSAIDs: Non-steroidal anti-inflammatory drugs.

Citation: Kubosawa Y, Mori H, Kinoshita S, Nakazato Y, Fujimoto A, Kikuchi M, Nishizawa T, Suzuki M, Suzuki H. Changes of gastric ulcer bleeding in the metropolitan area of Japan. World J Gastroenterol 2019; 25(42): 6342-6353
URL: https://www.wjgnet.com/1007-9327/full/v25/i42/6342.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i42.6342