Differentiating Crohn’s disease from intestinal tuberculosis

Table 6 Features included and the diagnostic accuracy of different multi-parametric predictive models for differentiating Crohn’s disease and intestinal tuberculosis

Parameters	Makharia 2010[7]		Li 2011[17]		Yu 2012[8]		Jung 2016[20]		Bae 2017[23]
Number of patients	CD	ITB	CD	ITB	CD	ITB	CD	ITB	CD	ITB
	53	53	130	122	53	43	162	99	40	40
Clinical	Bleeding PR Weight loss		Bleeding PR Surgery history Perianal disease		Night sweats		Age Gender Diarrhea		-
Endoscopic	Sigmoid colon involvement		Longitudinal ulcer Cobblestone appearance Transverse ulcer Rodent ulcer Rectal involvement Fixed open IC valve		Longitudinal ulcer		Transverse ulcer Longitudinal ulcer Sigmoid Colon involvement		Anorectal lesions Longitudinal ulcers Aphthous ulcers Cobblestone appearance Involvement < 4 segments Patulous IC valve Transverse ulcers Pseudopolyps
Pathologic	Focal enhanced colitis				Granuloma		-		-
Radiologic	-		PTB Ascites		-		Suspicious PTB		Proximal intestine PTB
Laboratory	-		Positive Mantoux		-		-		Positive ASCA Positive IGRA
AUROC	0.91		0.83		0.86		0.98		0.96
Sensitivity	83%		83%		67%		98%		95%
Specificity	79%		82%		93%		92%		97%

ASCA: Anti-saccharomyces cerevisiae antibody; CD: Crohn’s disease; IGRA: Interferon gamma release assays; ITB: Intestinal tuberculosis.