Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres

Table 4 Univariate analysis of progression-free survival and overall survival in patients with advanced mixed neuroendocrine non-neuroendocrine neoplasm

	PFS				OS
	n	Median (mo)	95%CI	P value	n	Median (mo)	95%CI	P value
Primary tumour site
Lower GI	35	6.6	4.6-7.4	0.008	37	9.6	5.21-15.2	< 0.001
PB	7	4.4	0.8-NR		7	4.4	2-NR
Upper GI	11	9.5	5.1-NR		11	9.5	5.1-NR
Unknown	1	1.3	-		1	1.3	-
Age at diagnosis
< 70 yr	32	5.9	4.3-9.5	0.19	32	9.5	5.2-16.3	0.23
≥ 70 yr	22	5.6	3.8-8.0		22	9.0	4.6-14.7
ECOG PS
0-1	36	6.9	4.6-8.2	0.9	36	9.6	5.216.3	0.45
≥ 2	13	5.9	3.4-NR		13	5.9	4.6-NR
Gender
Female	20	5.2	2.6-9.1	0.5	20	7.9	3.7-19.8	0.96
Male	34	6.9	4.6-9.5		34	9.0	5.2-15.2
Predominant component
ADC	11	4.4	2.6-NR	0.08	11	4.4	2.6-NR	0.14
EQUAL	6	9.5	4.4-NR		6	34.2	12.4-NR
NE	23	5.6	4.3-7.2		23	7.2	5.2-13.7
Grading NE component
G1	0				0
G2	5	6.9	5.2-NR	0.65	5	53.8	5.2-NR	0.34
G3	49	5.6	4.4-7.4		49	9.0	5.2-13.4
Ki-67 of NE component
< 55%	14	7.0	5.3-12.9	0.78		10.7	5.6-NR	0.6
≥ 55%	32	4.7	3.9-8.0			7.2	5.15-13.4
First line active treatment
No	13	2.2	1.6	< 0.001		3.7	2.0	< 0.001
Yes	40	7.1	5.2-9.8			13.4	9.0-16.3

PFS: progression free survival; OS: overall survival; 95%CI: 95% confidence interval; NR: Not reached; Lower GI: Lower gastrointestinal tract; Upper GI: Upper gastrointestinal tract; PB: Pancreatico-biliary tract; PS: Performance status; ECOG: Eastern Cooperative Oncology Group; ADC: Adenocarcinoma; EQUAL: Equal proportions of the two histologies; NE: Neuroendocrine component; Note: Advanced mixed neuroendocrine non-neuroendocrine neoplasms include both patients who presented with advanced disease at diagnosis and those who developed advanced recurrent disease after initial curative treatment. First line active treatment includes palliative surgery alone, palliative surgery combined with chemotherapy, chemotherapy alone, chemo-radiotherapy.