Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment

doi:10.3748/wjg.v25.i38.5883

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2019; 25(38): 5883-5896
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5883

Table 2 Assignment of risk of hepatocellular carcinoma development associated to each hepatitis B virus genetic variants

HCC risk	HBV region	Genetic variant
High
	PreS2	PreS2 deletions
	BCP	C1653T, T1753V (A/C/G), A1762T + G1764A
	Precore	G1896A, G1899A
Suspect
	PreS1	PreS1 deletions
	PreS2	T53C
	BCP	C1773T
	Precore	A1846T
	Core	C1914G, C2289A
Minor
	PreS1	T3098C, T3139A
	PreS2	PreS2 start codon
	S	T766A, T791A
	BCP	T1674C, G1727, C1741, C1761, C1766T, T1768A
	Precore	C1858T, G1862T
	Core	C1909, A1934T, C2002T, T2003A, C2100A, A2159G, A2189C, A2246C

High evidences: HBV mutants with positive data for HCC correlation evidenced in at least 3 different papers, or in meta-analysis studies; Suspected correlation: Positive data for HCC correlation evidenced in at least 2 works or without meta-analysis evidences; Minor evidences: Positive data for HCC correlation in single works. HCC: Hepatocellular carcinoma.

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Citation: Gil-García AI, Madejón A, Francisco-Recuero I, López-López A, Villafranca E, Romero M, García A, Olveira A, Mena R, Larrubia JR, García-Samaniego J. Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment. World J Gastroenterol 2019; 25(38): 5883-5896
URL: https://www.wjgnet.com/1007-9327/full/v25/i38/5883.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i38.5883

Gil-García AI, Madejón A, Francisco-Recuero I, López-López A, Villafranca E, Romero M, García A, Olveira A, Mena R, Larrubia JR, García-Samaniego J. Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment. World J Gastroenterol 2019; 25(38): 5883-5896 [PMID: 31636479 DOI: 10.3748/wjg.v25.i38.5883]

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