Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

Table 2 Univariate and multivariate analyses of prognostic factors for gastric cancer

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (> 60 vs < 60)	1.003 (0.618-1.628)	0.991
Gender (Female vs Male)	0.874 (0.639-1.195)	0.400
Differentiation (Poorly vs Well/moderately)	1.236 (0.760-2.009)	0. 393
TNM stage (III vs I-II)	3.714 (2.261-6.102)	< 0.001	2.676 (1.236-5.793)	0.013
T stage (T3-T4 vs T2-T1)	1.931 (1.178-3.165)	0.009
N stage (N1-N3 vs N0)	2.666 (1.599-4.448)	< 0.001	2.089 (1.169-3.732)	0.013
Chemotherapy outcome (SD/PD vs CR/PR)	3.254 (1.885-5.616)	< 0.001
WISP1 (High vs Low)	2.341 (1.385-3.956)	0.0019	2.180 (1.187-4.003)	0.012

CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; TNM: Tumor-node-metastasis; CI: Confidence interval; HR: Hazard ratio.