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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2019.
World J Gastroenterol. Oct 14, 2019; 25(38): 5732-5772
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5732
Table 5 Zinc transporters
Gene nameCancerRoleFunctional activity
ZnT1/SLC30A1PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZnT2/SLC30A2PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZnT3/SLC30A3PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZnT4/SLC30A4PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZnT5/SLC30A5ColorectalOncogeneIncreased mRNA expression in tumors[337]
ZnT6/SLC30A6ColorectalOncogeneIncreased mRNA expression in tumors[337]
ZnT7/SLC30A7Esophageal colorectalOncogene oncogeneIncreased mRNA expression in tumors[308,335] Increased mRNA expression in tumors[337]
ZnT8/SLC30A8PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZnT9/SLC30A9PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZIP1/SLC39A1GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDown regulated mRNA expression in tumors[313]
ZIP2/SLC39A2GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressormRNA expression down-regulated in tumors[313]
ZIP3/SLC39A3PancreaticTumor suppressorDecreased expression in adenocarcinoma[308,313,331,343]
OncogeneMedium to high mRNA expression in multiple human PC cell lines[313]
ZIP4/SLC39A4HepatocellularOncogeneIncreased mRNA and protein expression, repressed apoptosis, enhanced cell cycle and migration[308,325,344-346]
PancreaticOncogeneIncreased expression in PDAC and PC cell lines, link to CREB-miR-373 axis, promotes cancer xenograft growth in nude mice[313,325-327]
GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
ZIP5/SLC39A5EsophagealOncogeneIncreased expression in ESCC, knockdown in cell lines inhibited migration and invasion[308,334]
GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZIP6/LIV-1/SLC39A6PancreaticOncogeneIncreased expression in tumors and cell lines[313,330]
Tumor suppressorDecreased mRNA expression in tumors[313]
HepatocellularOncogeneIncreased mRNA and protein expression[308,347]
EsophagealOncogeneIncreased expression in ESCC[308,333]
ColorectalOncogeneIncreased mRNA expression in tumors[337]
GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
ZIP7/SLC39A7PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ColorectalOncogeneIncreased mRNA expression in tumors and CRC cell lines, knockdown inhibits cell growth and induces apoptosis in cell lines[339]
GastricUndeterminedIncreased mRNA expression, but better patient prognosis[338]
ZIP8/SLC39A8GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ZIP9/SLC39A9ColorectalOncogeneIncreased mRNA expression in tumors[337]
GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ZIP10/SLC39A10ColorectalOncogeneIncreased mRNA expression in tumors[337]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ZIP11/SLC39A11ColorectalOncogeneIncreased mRNA expression in tumors[337]
GastricUndeterminedIncreased mRNA expression in tumors, better patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ZIP12/SLC39A12GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
ZIP13/SLC39A13GastricOncogeneIncreased mRNA expression in tumors, worse patient prognosis[338]
PancreaticTumor suppressorDecreased mRNA expression in tumors[313]
OncogeneMedium to high mRNA expression in multiple human cell lines[313]
ZIP14/SLC39A14HepatocellularTumor suppressorDecreased expression in hepatoma tissues[308,348]
GastricUndeterminedIncreased mRNA expression in tumors, but better patient prognosis[338]
Tumor suppressorDecreased mRNA expression in tumors[313]
PancreaticOncogeneMedium to high mRNA expression in multiple human cell lines[313]
PDAC: Pancreatic ductal adenocarcinoma; ESCC: Esophageal squamous cell carcinoma; CRC: Colorectal cancer; PC: Pancreatic cancer.
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