Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer

Figure 2 ADAM28 is overexpressed in pancreatic cancer tissues. A: The TCGA database was used to evaluate the transcript of ADAM28 in pancreatic tumor tissues and adjacent normal pancreatic tissues. ^cP < 0.001 vs normal group; B: GSE16515 was included to analyze the ADAM28 gene levels in 36 pancreatic cancer tissues and 16 adjacent normal tissues. ^cP < 0.001 vs normal group; C: GSE15471 was included to analyze the ADAM28 gene levels in 36 pancreatic cancer tissues and 16 adjacent normal tissues. ^cP < 0.001 vs normal group; D: Difference of ADAM28 expression between basal and classical types of pancreatic cancer. ^cP < 0.001 vs normal group; ^aP < 0.05 vs basal group. TCGA: The Cancer Genome Atlas; PDAC: Pancreatic ductal adenocarcinoma.