Correlation of plasma miR-21 and miR-93 with radiotherapy and chemotherapy efficacy and prognosis in patients with esophageal squamous cell carcinoma

Table 8 Univariate and multivariate Cox regression analyses of factors affecting 3-year overall survival of esophageal squamous cell carcinoma patients

Index	Univariate		Multivariate
	HR (95%CI)	P-value	HR (95%CI)	P-value
Gender (male vs female)	1.178 (0.508-2.686)	0.713
Age (≤ 65 yr vs > 65 yr)	1.167 (0.439-3.158)	0.770
Smoking history (no vs yes)	0.631 (0.259-1.483)	0.288
History of alcoholism (no vs yes)	0.802 (0.447-1.459)	0.468
T stage (T2/T3 vs T4)	3.183 (1.762-5.783)	< 0.001b	3.168 (1.537-6.537)	0.003b
N stage (N0 vs N1)	1.318 (1.067-1.638)	0.015a	1.307 (1.057-1.736)	0.017a
M stage (M0 vs M1)	2.438 (1.934-3.062)	< 0.001b	1.735 (1.402-2.281)	<0.001b
Tumor site (Upper 1/3 vs middle 1/3 vs lower 1/3 of thoracic part)	1.289 (0.557-2.825)	0.548
Pathological differentiation (moderate/high differentiation vs low differentiation)	0.753 (0.567-1.008)	0.048a	0.802 (0.557-1.159)	0.243
Tumor length (≤ 5 cm vs > 5 cm)	0.687 (0.283-1.675)	0.394
Radiotherapy and chemotherapy (effective vs ineffective)	1.695 (1.237-2.248)	0.001b	1.335 (0.975-1.846)	0.080
MiR-21 (≤ 5.60 vs > 5.60)	4.083 (2.158-7.763)	< 0.001b	2.438 (1.276-4.71)	0.007b
MiR-93 (≤ 3.87 vs > 3.87)	4.485 (1.993-10.067)	< 0.001b	2.198 (1.256-3.875)	0.009b

^aP < 0.05 vs control group;

^bP < 0.01 vs control group. HR: Hazard ratio; CI: Confidence interval.